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KMID : 1134820120410020168
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Journal of the Korean Society of Food Science and Nutrition
2012 Volume.41 No. 2 p.168 ~ p.173
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Antithrombotic Effect and Antiplatelet Activity of Polygonum cuspidatum Extract
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Yang Won-Kyung
Sung Yoon-Young
Kim Ho-Kyoung
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Abstract
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We performed this study to develop antithrombotic agents from oriental medicine herb extracts. Polygonum cuspidatum has been traditionally used as an edible medical resources for the treatment of cancer, pyodermatitis, hepatitis, cystitis, and inflammation. However, the effects of Polygonum cuspidatum on thrombosis and platelet activation are not precisely understood. The antithrombotic and antiplatelet activities of Polygonum cuspidatum were investigated by assessing the effect of a 70% ethanol extract of Polygonum cuspidatum on blood coagulation, fibrinolysis, and platelet aggregation. Polygonum cuspidatum showed effective fibrinolytic activity at 10 mg/mL. Polygonum cuspidatum also inhibited adenosine diphosphate induced platelet aggregation. Furthermore, evaluation of anticoagulant activity showed that an extract of Polygonum cuspidatum prolonged coagulation time via activated partial thromboplastin time (APTT). Our results show that Polygonum cuspidatum can be a potential candidate for antiplatelet activity as well as a fibrinolytic agent.
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KEYWORD
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antithrombotic activity, platelet aggregation, blood coagulation, fibrinolysis, Polygonum cuspidatum
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